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Abstract #3044

A novel RXDLXXL-coupled peptide-conjugated USPIO nanoparticles for integrin αvβ6-targeted MR molecular imaging

Dengfeng Li1, Xiaohong Ma1, Chengyan Dong2, and Xinming Zhao1
1Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2GE Healthcare, Beijing, China

Integrin αvβ6 is considered a promising molecular imaging target because it is significantly up-regulated in various types of cancers and correlates with the survival time of patients. MR imaging has advantages of non-invasive, non-radioactive, high soft-tissue contrast, and multiparameter imaging. Therefore, this study synthesized an integrin αvβ6-targeted nanoparticle probe for MR molecular imaging. Our experiments showed that novel targeted nanoparticles can specifically bind with integrin αvβ6 overexpressed cells in vitro and in vivo, presenting potential applications in the fields of αvβ6-positive tumor targeted MR molecular imaging.

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