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Abstract #3045

Sub-5 nm Ultrafine Iron Oxide Nanoparticles for T1-Weighted MRI of Brain Tumors in Intracranial Mouse Model of Glioma

Yuancheng Li1, Yaolin Xu1, Kecheng Lei2, Bing Ji1, Seong Kang2, Keqiang Ye2, and Hui Mao1
1Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States

Sub-5 nm ultrafine iron oxide nanoparticles (uIONP) is capable of entering intracranial U87 brain tumors in mice, leading to T1-contrast enhancement in the tumor similar to the clinically used gadolinium chelate contrast agents. The intra-tumoral accumulation of uIONP was supported by in vivo and ex vivo NIR imaging of NIR830-labeled uIONP and histological analysis. The developed uIONPs demonstrated faster clearance via kidney and liver comparing to conventional IONPs with larger sizes. Further development of uIONP-based MRI probes and drug carriers can provide a theranostic platform for precision medicine in brain tumors.

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