Abstract #3049

New class of biodegradable responsive phosphorus–containing contrast agent for 1H/31P MR

Natalia Ziółkowska^1,2, Martin Hrubý³, Martin Vít^1,4, Zdislava Pechrová^3,5, and Daniel Jirák^1,2

¹Department of Computed Tomography, Magnetic Resonance and Clinical Experimental Spectroscopy, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²First Faculty of Medicine, Institute of Biophysics and Informatics, Charles University, Prague, Czech Republic, ³Supramolecular polymer systems department, Institute of Macromolecular Chemistry, Prague, Czech Republic, ⁴Faculty of Mechatronics Informatics and Interdisciplinary Studies, Technical University of Liberec, Liberec, Czech Republic, ⁵Faculty of Sciences, Department of Physical and Macromolecular Chemistry, Charles University, Prague, Czech Republic

We present a new class of biodegradable responsive ³¹P phosphorus–containing contrast agent for dual ¹H/³¹P MRI. Both ¹H and ³¹P MR imaging modalities offer complementary information and can be easily combined at the same experiment. The switch to phosphorus MR signal can reflect biochemical changes in the organism. An implementation for ¹H/³¹P MR at 4.7 T is presented and its properties are investigated.

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