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Abstract #3048

NanoGd, a novel hybrid multimodal nanoparticle designed for inflammation imaging: pre-clinical evaluation in ischemic stroke

Violaine Hubert1, Ines Hristovska2, Szilvia Karpati3, Frederic Lerouge3, Maelle Monteil4, Emmanuel Brun5, Naura Chounlamountri2, Chantal Watrin2, Fabien Chauveau6, Yves Berthezene7, Marc Lecouvey4, Stephane Parola3, Olivier Pascual2, and Marlene Wiart1
1Université Lyon, CarMeN laboratory, Inserm U1060, Lyon, France, 2Université Lyon Institut Neuromyogène CNRS UMR 5310, INSERM U1217, Lyon, France, 3Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5182, Université Lyon 1, Laboratoire de Chimie, Lyon, France, 4Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, Paris, France, 5STROBE team, European Synchrotron Radiation Facility, Grenoble, France, 6Université Lyon, Lyon Neuroscience Research Center, CNRS UMR5292, Inserm U1028, Lyon, France, 7Université Lyon, CREATIS CNRS UMR 5220-INSERM U1206, Lyon, France

We here report the first quantitative study using MRI and intravital two-photon microscopy back-to-back to image inflammation in a mouse model of permanent middle cerebral artery occlusion, thanks to NanoGd, a new multimodal nanoparticle. Overall, our data suggest that NanoGd is safe and does not induce inflammation. NanoGd is phagocytosed by Macrophages/Microglia both in-vitro and in-vivo. In permanent ischemic stroke, NanoGd-enhanced MRI allows to visualize inflamed areas within the ischemic lesion and thus appears as a promising tool for the evaluation of anti-inflammatory treatments.

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