Abstract #3048

NanoGd, a novel hybrid multimodal nanoparticle designed for inflammation imaging: pre-clinical evaluation in ischemic stroke

Violaine Hubert¹, Ines Hristovska², Szilvia Karpati³, Frederic Lerouge³, Maelle Monteil⁴, Emmanuel Brun⁵, Naura Chounlamountri², Chantal Watrin², Fabien Chauveau⁶, Yves Berthezene⁷, Marc Lecouvey⁴, Stephane Parola³, Olivier Pascual², and Marlene Wiart¹

¹Université Lyon, CarMeN laboratory, Inserm U1060, Lyon, France, ²Université Lyon Institut Neuromyogène CNRS UMR 5310, INSERM U1217, Lyon, France, ³Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5182, Université Lyon 1, Laboratoire de Chimie, Lyon, France, ⁴Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, Paris, France, ⁵STROBE team, European Synchrotron Radiation Facility, Grenoble, France, ⁶Université Lyon, Lyon Neuroscience Research Center, CNRS UMR5292, Inserm U1028, Lyon, France, ⁷Université Lyon, CREATIS CNRS UMR 5220-INSERM U1206, Lyon, France

We here report the first quantitative study using MRI and intravital two-photon microscopy back-to-back to image inflammation in a mouse model of permanent middle cerebral artery occlusion, thanks to NanoGd, a new multimodal nanoparticle. Overall, our data suggest that NanoGd is safe and does not induce inflammation. NanoGd is phagocytosed by Macrophages/Microglia both in-vitro and in-vivo. In permanent ischemic stroke, NanoGd-enhanced MRI allows to visualize inflamed areas within the ischemic lesion and thus appears as a promising tool for the evaluation of anti-inflammatory treatments.

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