Low back pain is a leading cause of job-related disability and missed workdays in the U.S. Unfortunately, the overall treatment effectiveness is significantly limited by our poor diagnostic capability, which fails to identify nociceptive sources in 80% to 90% of the cases. In this work, we introduce a PET/MRI approach for low back pain diagnosis using a novel radioligand to track the sigma-1 receptor, which is upregulated during nociceptive processes. Our early results demonstrate promise in achieving improved sensitivity and specificity to the local sources of low back pain.
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