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Abstract #3059

Construction of mGluR5 receptor based in vivo atlas using simultaneously acquired [11C]ABP688 PET / MR data

Nicolas Kaulen1,2, Claudia Régio Brambilla1,3,4, Ravichandran Rajkumar1,3,4, Shukti Ramkiran1,3, Linda Orth1,3, Hasan Sbaihat1, Markus Lang5, Elena Rota Kops1, Jürgen Scheins1, Bernd Neumaier5, Johannes Ermert5, Hans Herzog1, Karl-Josef Langen1,4,6, Christoph Lerche1, N. J. Shah1,4,7,8, and Irene Neuner1,3,4
1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, 2Faculty of Physics, Technical University Dortmund, Dortmund, Germany, 3Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 4JARA – BRAIN – Translational Medicine, Aachen, Germany, 5Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany, 6Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 7Institute of Neuroscience and Medicine 11, INM-4, Forschungszentrum Jülich, Jülich, Germany, 8Department of Neurology, RWTH Aachen University, Aachen, Germany

This project aims to create a standard space in vivo atlas of the mGluR5 distribution in the healthy brain using structural and metabolic information from simultaneously acquired [11C]ABP688-PET / MR data. The structural MRI scans served as an anatomical reference to create a parametric MNI space atlas of mGluR5 non-displaceable binding potential. Validation of the atlas was performed and global as well as local reductions of mGluR5 availability in healthy smokers and schizophrenic smokers that are in line with the results of previous studies could be shown. Preliminary investigation of schizophrenic non-smokers showed slight, though not conclusive, reductions of mGluR5.

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