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Abstract #3058

Hippocampal Subfield Tau Progression Identified using Simultaneous Tau-PET/MRI at 3T in Alzheimer’s Disease

Mackenzie Leigh Carlson1, Tyler Toueg2, Mehdi Khalighi3, Jessa Castillo3, Bin Shen3, Carmen Azevedo3, Phillip DiGiacomo1, Nicole Mouchawar3, Greg Zaharchuk3, Michelle James2,3, Elizabeth Mormino2, and Michael Zeineh3
1Bioengineering, Stanford University, Stanford, CA, United States, 2Neurology, Stanford University, Stanford, CA, United States, 3Radiology, Stanford University, Stanford, CA, United States

We found structural changes and tau protein accumulation within the hippocampus that can be simultaneously assessed at the subfield level in Alzheimer’s Disease. We found more separation among AD, mild cognitive impairment (MCI), and control groups when considering subfields than whole hippocampal SUVr. This study highlights the potential of our combined subfield analysis technique in disentangling pathologic derangements accompanying AD in the hippocampus and for providing more nuanced imaging-based measures for tracking and staging disease in vivo.

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