Abstract #3057

TSPO-PET/MRI Reveals Increased Neuroinflammation in Basal Ganglia of Chronic Fatigue Syndrome Patients

Mackenzie Leigh Carlson¹, Jun-Hyung Park², Tullia Lieb³, Bin Shen², Marc Stevens², Brian Mills², Nicole Mouchawar², Greg Zaharchuk², Michael Zeineh², and Michelle James^2,4

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Medicine, Stanford University, Stanford, CA, United States, ⁴Neurology, Stanford University, Stanford, CA, United States

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease affecting millions of people in the United States alone, but little is known about the underlying pathophysiology. We show that simultaneous TSPO-PET/MRI measurements using [¹¹C]DPA-713, including SUV, SUVr, QSM, R2*, and volume can uncover new information about this disease. We find that the putamen has significantly higher TSPO-PET signal in ME/CFS subjects compared to healthy controls, indicating an elevated inflammatory response in this area. This finding corresponds to previous fMRI and diffusion imaging findings and may help with future diagnosis and tracking of this chronic, widespread disease.

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