The purpose of this study was to characterize the contribution of fat to the CEST signal when using a water-selective binomial-pulse excitation and the effects of multiple fat peaks and B0 inhomogeneity. A CEST sequence with binomial-pulse excitation and a modified PRESS localization was applied to in vivo experiments to determine signal contributions of lipid resonances. Water excitation using a {1-3-3-1} pulse provided a broad signal suppression, which provided robustness against B0 inhomogeneity. Significant fat signal contributions to CEST imaging of hydroxyl and amine were unavoidable, while much smaller contamination was seen when imaging amide sites, limited by B0 inhomogeneity.
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