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Abstract #3062

The utility of trastuzumab-based imaging agents for the development of theranostic for breast cancer

Xiaojun Luo1, Chunwu Zhou2, and Lizhi Xie3
1Department of Radiology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China, 2National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3GE healthcare, China, Beijing, China

Superparamagnetic iron oxide nanoparticles (SPIONs) has been applied in diagnosis of different cancers, however its potential in breast cancer has not been fully explored. In this study, we research into the value of SPIONs conjugated with trastuzumab and indocyanine green (ICG) in becoming an effective multifunctional imaging agent and a tool for photothermal therapy for HER2-positive breast cancer. It was found that the biodistribution of dual-modality imaging agents has been observed by MRI and fluorescence imaging, which could provide effective technical assistance for HER2-positive breast cancer treatment.

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