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Abstract #3064

In vivo three-dimensional evaluation of hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT

Wenhui Huang1,2, Kun Wang2, Jie Tian2, and Shuixing Zhang1
1the First Affiliated Hospital,Jinan University, Guangdong, China, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China

The accurate imaging hypoxia is especially vital for nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. Multimodality molecular imaging have great potential to acquire hypoxic imaging with high sensitivity and more accuracy. We propose a novel imaging strategy,which combined the hybrid fluorescence molecular tomography-computed tomography (FMT-CT) and the multispectral optoacoustic tomography (MSOT), for achieving three-dimensional (3D) quantitative evaluation of NPC hypoxia in small animal models.The results could not only detect the hypoxia in small sizes of NPCs and lymph nodes metatasis, but also visualize the heterogeneity of hypoxia in 3D.

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