Abstract #3066

Molecular MRI and synchrotron radiation X-Ray fluorescence of zinc homeostasis in the healthy and malignant mouse prostate

Veronica Clavijo Jordan ¹, Andre Martins^2,3, Erica Dao⁴, Alia Al-Ebraheem⁴, Kalotina Geraki⁵, Xiaodong Wen³, Sara Chirayil³, Xiaojing Wang³, Mozhdeh Sojoodi⁶, Michael Farqhuarson⁴, and A.Dean Sherry^3,7

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, United States, ²Werner Siemens Imaging Center, Tuebingen, Germany, ³Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴McMaster University, Hamilton, ON, Canada, ⁵Diamond Light Source, Harwell, United Kingdom, ⁶Division of Surgical Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States, ⁷Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States

Zinc homeostasis is markedly dysregulated in prostate cancer (PCa), and this dysregulation can be detected with glucose-stimulated zinc secretion (GSZS) by MRI. Here we explore the use of GSZS MRI and synchrotron-radiation X-Ray fluorescence to interrogate the effect of dietary zinc on the healthy and malignant mouse prostate. Our results indicate that the lateral lobe of the healthy mouse is the only prostatic structure responsive to a variable zinc diet acting as the zinc “regulator” of the gland, and that in PCa this lobe no longer responds to changes in dietary zinc, highlighting the dysregulation of zinc transporters in PCa.

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