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Abstract #3066

Molecular MRI and synchrotron radiation X-Ray fluorescence of zinc homeostasis in the healthy and malignant mouse prostate

Veronica Clavijo Jordan 1, Andre Martins2,3, Erica Dao4, Alia Al-Ebraheem4, Kalotina Geraki5, Xiaodong Wen3, Sara Chirayil3, Xiaojing Wang3, Mozhdeh Sojoodi6, Michael Farqhuarson4, and A.Dean Sherry3,7
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, United States, 2Werner Siemens Imaging Center, Tuebingen, Germany, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4McMaster University, Hamilton, ON, Canada, 5Diamond Light Source, Harwell, United Kingdom, 6Division of Surgical Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States, 7Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States

Zinc homeostasis is markedly dysregulated in prostate cancer (PCa), and this dysregulation can be detected with glucose-stimulated zinc secretion (GSZS) by MRI. Here we explore the use of GSZS MRI and synchrotron-radiation X-Ray fluorescence to interrogate the effect of dietary zinc on the healthy and malignant mouse prostate. Our results indicate that the lateral lobe of the healthy mouse is the only prostatic structure responsive to a variable zinc diet acting as the zinc “regulator” of the gland, and that in PCa this lobe no longer responds to changes in dietary zinc, highlighting the dysregulation of zinc transporters in PCa.

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