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Abstract #3067

Quantitative PET/MRI of Immunotherapy Response in Preclinical Epithelial Ovarian Cancer

Marie-Laurence Tremblay1,2,3, Caitrin Sobey-Skelton1,2, Hailey Wyatt1,2, Victoria Gonzalez2, Andrea Nuschke1,4, Christa Davis1, Alecia MacKay5, Kim Bobbitt5, Andrea West2,5, Barbara Vanderhyden6,7, Genevieve Weir5, Marianne Stanford5, and Kimberly Brewer1,2
1Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, 2Dalhousie University, Halifax, NS, Canada, 3IWK Inc., Halifax, NS, Canada, 4Carleton University, Ottawa, ON, Canada, 5IMV Inc., Halifax, NS, Canada, 6Ottawa Hospital Research Institution, Ottawa, ON, Canada, 7University of Ottawa, Ottawa, ON, Canada

Epithelial ovarian cancers are highly aggressive tumor types making them a prime target for research using immunotherapies. Using simultaneous PET/MRI, we monitored an orthotopic ovarian cancer model to evaluate longitudinal tumor growth and metabolism in response to therapy while tracking immune cell subsets labeled with superparamagnetic iron oxide (SPIO). Treatment with the combination of immune therapies significantly decreased the volume of primary tumors and improved survival times. We quantified cytotoxic T lymphocytes (CTLs) and dendritic cells (DCs) recruited to the primary tumors and found treatment with the combination therapy increased recruitment of CTLs but resulted in decreased recruitment of DCs.

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