Epithelial ovarian cancers are highly aggressive tumor types making them a prime target for research using immunotherapies. Using simultaneous PET/MRI, we monitored an orthotopic ovarian cancer model to evaluate longitudinal tumor growth and metabolism in response to therapy while tracking immune cell subsets labeled with superparamagnetic iron oxide (SPIO). Treatment with the combination of immune therapies significantly decreased the volume of primary tumors and improved survival times. We quantified cytotoxic T lymphocytes (CTLs) and dendritic cells (DCs) recruited to the primary tumors and found treatment with the combination therapy increased recruitment of CTLs but resulted in decreased recruitment of DCs.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords