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Abstract #3070

Spatial relationship between brain tumor regions assessed by PWI and 11C-Methionine using a fully hybrid PET/MRI system

Paola Scifo1, Maurizio Barbera2, Federico Fallanca1, Antonella Castellano2, Paola Mapelli1, Valentino Bettinardi1, Annarita Savi1, Riccardo Rigamonti1, Andrea Falini2, Luigi Gianolli1, Maria Picchio1,3, and Nicoletta Anzalone2
1Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neuroradiology and CERMAC, VIta-Salute University, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy

Simultaneous PET/MRI offers a unique opportunity to investigate the relationship between concurrent phenomena measured by MET-PET and PWI-MR at the same physiological condition. Although 11C-Methionine uptake and perfusion are tightly coupled, it is not clear whether tumor regions (VOIs) defined by PWI and MET are overlapped and how the values of the corresponding parametric maps are distributed within each VOI. This preliminary work aims at studying the spatial relationship between PWI-MRI maps and MET-PET in brain tumors using a fully integrated PET/MRI system.

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