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Abstract #3071

In Vivo Effect of Gadolinium-Based Contrast Agent on PET Quantification for Breast Imaging

Timothy J Allen1, Leah C Henze Bancroft2, Manoj Kumar2, Tyler Bradshaw2, Roberta M Strigel1,2,3, Alan McMillan1,2, and Amy M Fowler1,2,3
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States

The effect of gadolinium-based contrast agents (GBCAs) on dynamic PET quantification was investigated. Simultaneous PET/MRI was performed in patients with biopsy confirmed invasive breast cancer. Subjects received an injection of a GBCA as part of standard clinical dynamic contrast enhanced breast MRI exam. SUVmean and SUVmax were calculated for the biopsy-proven breast cancer, aorta, liver, and benign fibroglandular tissue prior to and following GBCA injection. No significant difference in SUVmean or SUVmax was measured suggesting GBCAs are unlikely to affect PET quantification in combined breast PET/MRI.

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