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Abstract #3075

Early experience in identifying chronic pelvic pain generators by sigma-1 receptor PET/MRI 

Daehyun Yoon1, Angela Fast2, Peter Cipriano1, Bin Shen1, Michelle James1, Deirdre Lum3, and Sandip Biswal1
1Radiology, Stanford university, Stanford, CA, United States, 2Diagnostic, Molecular and Interventional Radiology, The Mount Sinai Hospital, New York, NY, United States, 3Gynecology, Stanford university, Palo Alto, CA, United States

Chronic pelvic pain is a highly prevalent pain condition among women, but it is quite challenging to determine the exact cause of pain. MRI is currently the imaging modality of choice, but even the most common etiology is very difficult to identify. In this abstract, we introduce a novel PET/MRI approach for chronic pelvic pain diagnosis to achieve improved sensitivity by enabling image tracking of sigma-1 receptor, a chaperone protein modulating ion channels for activating nociceptive processes. Our early results present promising results in identifying potential pain generators of chronic pelvic pain, which could not be detected in MRI alone.

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