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Abstract #3076

Orthotopic Brain Tumor Imaging and Therapy by Microenvironment-Responsive Gold Nanoclusters

Haiyan Gao1, Yan Bai1, Lijuan Chen1, and Meiyun Wang1
1Henan Provincial People's Hospital, Zhengzhou, China

Glioblastoma is one of the most lethal cancers with few available therapeutic options. Herein, we report a in situ self-assembled nanoplatform formed by RGD peptide-modified Bisulfite-ZincII-Dipicolylamine-Arg-Gly-Asp (Bis(DPA-Zn)-RGD) and ultrasmall Au-ICG nanoparticles. Taking advantage of RGD-mediated neovascular targeting, the Bis(DPA-Zn)-RGD selectively navigates to the tumor site, and then assembles into large nanoclusters with subsequently administered Au-ICG nanoclusters which can successfully cross the BBB due to ultrasmall particle size (~7 nm). This study demonstrates that such in situ self-assembly metal–organic nanosystems are ideal to overcome the BBB and BBTB, which promise a new way for orthotopic brain tumors imaging and therapy.

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