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Abstract #3078

In-Vitro HyperCEST detection of decacationic pillar-5-areneĀ 

Camryn Jayne Newman1, Yurii Shepelytskyi2,3, Ashvin Fernando4, Paul T Cesana4, Tao Li5, Alanna Wade5, Vira Grynko3, Adriana M Mendieta4, Francis T Hane2,5, Brenton DeBoef4, and Mitchell S Albert2,5,6
1Biology, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada, 3Chemistry and Material Science, Lakehead University, Thunder Bay, ON, Canada, 4Chemistry, University of Rhode Island, Kingston, RI, United States, 5Chemistry, Lakehead University, Thunder Bay, ON, Canada, 6Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Hyperpolarized (HP) 129Xe molecular imaging technology has been working towards the detection of biochemically inactive supramolecular cage-molecules within a living mammalian model. The issue originates from the non-specific natural biodistribution of the biosensor molecules, which makes it difficult to precisely localize them within a living mammalian body using HP 129Xe MRI. We have previously identified cyclodextrin-based pseudorotaxanes and benzene-appended CB6 as conjugatable scaffolds for xenon biosensors; in this work, we introduce a third class of conjugatable scaffolds, with the hyperCEST detection of pillar[5]arene, a potential precursor to a large variety of targeted molecular imaging probes.

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