Abstract #3078

In-Vitro HyperCEST detection of decacationic pillar-5-arene

Camryn Jayne Newman¹, Yurii Shepelytskyi^2,3, Ashvin Fernando⁴, Paul T Cesana⁴, Tao Li⁵, Alanna Wade⁵, Vira Grynko³, Adriana M Mendieta⁴, Francis T Hane^2,5, Brenton DeBoef⁴, and Mitchell S Albert^2,5,6

¹Biology, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada, ³Chemistry and Material Science, Lakehead University, Thunder Bay, ON, Canada, ⁴Chemistry, University of Rhode Island, Kingston, RI, United States, ⁵Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁶Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Hyperpolarized (HP) 129Xe molecular imaging technology has been working towards the detection of biochemically inactive supramolecular cage-molecules within a living mammalian model. The issue originates from the non-specific natural biodistribution of the biosensor molecules, which makes it difficult to precisely localize them within a living mammalian body using HP 129Xe MRI. We have previously identified cyclodextrin-based pseudorotaxanes and benzene-appended CB6 as conjugatable scaffolds for xenon biosensors; in this work, we introduce a third class of conjugatable scaffolds, with the hyperCEST detection of pillar[5]arene, a potential precursor to a large variety of targeted molecular imaging probes.

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