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Abstract #3079

Evaluation of Cucurbit[6]uril Diffusion Across an Artificial Blood-Brain Barrier

Camryn Jayne Newman1, Yurii Shepelytskyi2,3, Michael Campbell2,4, Vira Grynko2,3, Francis Theodor Hane3,4, and Mitchell Scott Albert4,5
1Biology, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada, 3Chemistry and Material Science, Lakehead University, Thunder Bay, ON, Canada, 4Chemistry, Lakehead University, Thunder Bay, ON, Canada, 5Northern Ontario School of Medicine, Thunder Bay, ON, Canada

The selective nature of the blood-brain barrier (BBB) is highly regarded when evaluating the permeability of a molecule such as Cucurbit[6]uril (CB6). CB6 has previously demonstrated a strong hyperCEST effect, which makes it a valid candidate for detecting low concentrations of biomarkers of neurodegenerative pathologies. However, CB6 must be permeable to the BBB to use the hyperCEST technique for neurological biomarkers. Therefore, this work evaluates the permeability of CB6 across an artificial BBB based on diffusion. It was found that CB6 can cross the brain sphingomyelin powder (BSM) based artificial BBB.

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