The current standard methods for magnetic resonance imaging of superparamagnetic iron oxide nanoparticles (SPIONs) can be subject to “1/f” physiological fluctuations that can confound pre/post comparisons. We present a method to combine Block Design contrast Modulations and statistical analysis with the bSSFP sequence (BDM-bSSFP) in order to mitigate this effect. To do this, we leverage the frequency response of the bSSFP sequence to the local fields created by SPIONs. We show the ability of this method to detect SPIONs down to 10 μg/mL through simulations and in-vitro acquisitions.
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