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Abstract #3082

Monitoring Inflammation-associated Metabolic Alterations by Deuterium MRS

Vera Flocke1, Pascal Bouvain1, Sebastian Temme1, and Uli Flögel1
1Molecular Cardiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

There is increasing evidence that inflammatory diseases go along with substantial changes in intermediatory metabolism. Also it is known that metabolic syndrome is characterized by chronic low-grade inflammation in multiple organs[1,2]. In this context, the metabolism of glucose is of major interest, since in particular in the initial phase of an inflammation infiltrating immune cells mainly rely on glycolysis to cover their energy demand.

The present study demonstrates that 2H MRI can be successfully used for monitoring metabolic alterations in an inflammatory environment with a switch to a more anaerobic glucose utilization in the initial phase of immune cell recruitment.

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