Abstract #3084

Assessment of Passive Tumor Targeting of a Novel PFCE-Loaded Nanoemulsion via 19F-MRI

Lawrence M Lechuga¹, Alexa R Barres², Montira Tangsangasaksri³, Paul Begovatz¹, Sandro Mecozzi^3,4, and Sean B Fain^1,5,6

¹Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, ²Morgridge Institute for Research, Madison, WI, United States, ³Pharmacy, University of Wisconsin, Madison, Madison, WI, United States, ⁴Chemistry, University of Wisconsin, Madison, Madison, WI, United States, ⁵Biomedical Engineering, University of Wisconsin, Madison, Madison, WI, United States, ⁶Radiology, University of Wisconsin, Madison, Madison, WI, United States

Fluorine-19 MRI is a method that can utilize biocompatible perfluorocarbons to detect cancer. Implementation of a novel nanoemulsion has allowed for improved particle stability and PFC loading. Tumor-bearing mice were injected with perfluoro-[15-crown-5]-ether (PFCE) loaded nanoemulsion (NE) to explore the passive tumor targeting across 14 days. ¹⁹F MRI and subsequent ROI-image analysis suggested that there was a preferential retention of NE particles due to the enhanced permeability and retention (EPR) effect. This work demonstrates repeatable ¹⁹F imaging of a novel nanoemulsion that passively targets a fast growing tumor with improved stability and PFCE loading.

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