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Abstract #3084

Assessment of Passive Tumor Targeting of a Novel PFCE-Loaded Nanoemulsion via 19F-MRI

Lawrence M Lechuga1, Alexa R Barres2, Montira Tangsangasaksri3, Paul Begovatz1, Sandro Mecozzi3,4, and Sean B Fain1,5,6
1Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, 2Morgridge Institute for Research, Madison, WI, United States, 3Pharmacy, University of Wisconsin, Madison, Madison, WI, United States, 4Chemistry, University of Wisconsin, Madison, Madison, WI, United States, 5Biomedical Engineering, University of Wisconsin, Madison, Madison, WI, United States, 6Radiology, University of Wisconsin, Madison, Madison, WI, United States

Fluorine-19 MRI is a method that can utilize biocompatible perfluorocarbons to detect cancer. Implementation of a novel nanoemulsion has allowed for improved particle stability and PFC loading. Tumor-bearing mice were injected with perfluoro-[15-crown-5]-ether (PFCE) loaded nanoemulsion (NE) to explore the passive tumor targeting across 14 days. 19F MRI and subsequent ROI-image analysis suggested that there was a preferential retention of NE particles due to the enhanced permeability and retention (EPR) effect. This work demonstrates repeatable 19F imaging of a novel nanoemulsion that passively targets a fast growing tumor with improved stability and PFCE loading.

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