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Abstract #3085

Hyperpolarization and 1H-based detection of [15N]carnitine, a new long-lived metabolic imaging probe

Cornelius von Morze1, James D Quirk1, John A Engelbach1, Galen D Reed2, Albert P Chen2, Craig R Malloy3, Joel R Garbow1, and Matthew E Merritt4
1Department of Radiology, Washington University, St Louis, MO, United States, 2GE Healthcare, Dallas, TX, United States, 3Advanced Imaging Research Center, UT Southwestern, Dallas, TX, United States, 4Department of Biochemistry and Molecular Cell Biology, University of Florida, Gainesville, Gainesville, FL, United States

13C hyperpolarization has opened the door for real-time MR metabolic imaging but remains limited by T1's of approximately one minute or less. 15N offers potentially much longer T1's, but suffers from poor intrinsic sensitivity and small chemical-shift separation. We have hyperpolarized L-[15N]carnitine-d9, a novel metabolic imaging probe, and found ultra-long T1's of 210s (in H2O) / 160s (in vivo). We also demonstrate successful 15N->1H hyperpolarization transfer for enhanced sensitivity of detection as well as larger chemical-shift separation among metabolites. The long signal lifetime and excellent safety profile of [15N]carnitine suggest great potential for metabolic imaging investigations and future clinical translation.

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