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Abstract #3086

Optimization of glucose infusion protocol for glucoCEST imaging

Anina Seidemo1, Patrick M. Lehmann1, Anna Rydhög2, Ronnie Wirestam1, Xiang Xu3,4, Akansha A. Sehgal3,4, Yi Zhang5, Frederik Testud6, Pia C. Sundgren7,8, Peter C.M. van Zijl3,4, and Linda Knutsson1,3
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Centre for Medical Imaging and Physiology, Skåne University Hospital, Lund and Malmö, Sweden, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, 6Siemens Healthcare AB, Malmö, Sweden, 7Department of Diagnostic Radiology, Lund University, Lund, Sweden, 8Lund University Bioimaging Center, Lund University, Lund, Sweden

The intravenous glucose injection used in dynamic glucose-enhanced (DGE) imaging is related to transient sensations which can be unpleasant for the subject and may cause movements. We have investigated the effect of different infusion durations in terms of sensational side effects and with respect to the relation between arterial DGE signal and venous blood glucose levels. Our findings indicate that the DGE image quality does not benefit from a fast glucose injection and we conclude that a slower infusion should be used to increase patient comfort and reduce the risk for patient motion related to the glucose injection.

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