Abstract #3086

Optimization of glucose infusion protocol for glucoCEST imaging

Anina Seidemo¹, Patrick M. Lehmann¹, Anna Rydhög², Ronnie Wirestam¹, Xiang Xu^3,4, Akansha A. Sehgal^3,4, Yi Zhang⁵, Frederik Testud⁶, Pia C. Sundgren^7,8, Peter C.M. van Zijl^3,4, and Linda Knutsson^1,3

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Centre for Medical Imaging and Physiology, Skåne University Hospital, Lund and Malmö, Sweden, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁶Siemens Healthcare AB, Malmö, Sweden, ⁷Department of Diagnostic Radiology, Lund University, Lund, Sweden, ⁸Lund University Bioimaging Center, Lund University, Lund, Sweden

The intravenous glucose injection used in dynamic glucose-enhanced (DGE) imaging is related to transient sensations which can be unpleasant for the subject and may cause movements. We have investigated the effect of different infusion durations in terms of sensational side effects and with respect to the relation between arterial DGE signal and venous blood glucose levels. Our findings indicate that the DGE image quality does not benefit from a fast glucose injection and we conclude that a slower infusion should be used to increase patient comfort and reduce the risk for patient motion related to the glucose injection.

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