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Abstract #3093

Protein-sensitive CEST-MRI of Alzheimer’s patients at 3 T

Steffen Goerke1, Johannes Breitling1, Katharina M. Kubera2, Moritz Zaiss3, Dusan Hirjak4, Robert C. Wolf2, Anoshirwan A. Tavakoli5, Heinz-Peter Schlemmer5, Daniel Paech5, Mark E. Ladd1, and Peter Bachert1
1Divsion of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Center for Psychosocial Medicine, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany, 3Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany, 4Departement of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 5Departement of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, the potential of CEST-MRI as a tool for diagnostic imaging of Alzheimer’s patients was evaluated. Although the study size was yet too small to draw final conclusions, a significant decrease of the rNOE-CEST signal in Alzheimer’s patients was observed. This finding was in line with previous in vitro studies on the monitoring of protein aggregation using CEST-MRI. A diagnostic tool for Alzheimer’s based on CEST-MRI would allow avoiding invasive examinations and thus more frequent follow-ups allowing an improved level of patient care.

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