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Abstract #3092

Investigation of a parallel transmission (pTx) GRE-readout with customized pulses for CEST MRI at 7 Tesla  

Katharina Tkotz1, Andrzej Liebert1, Jürgen Herrler2, Patrick Liebig3, Arnd Dörfler2, Michael Uder1, Moritz Zaiss2,4, and Armin M. Nagel1,5
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 5Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

In Chemical Exchange Saturation Transfer MRI B1+-inhomogeneity influences both saturation and acquisition of the signal. Typically only a correction of the inhomogeneity of the CEST saturation is performed while the inhomogeneity of the readout is neglected. The influence of the readout was investigated in measurements using standard inhomogeneous 1Tx readout and a homogenized readout with customized pTx pulses. Compared to the 1Tx readout the readout with pTx pulses shows an increase of the homogeneity of the CEST contrast for CEST agents with low SNR like the amides and in regions with low 1Tx flip angle like the cerebellum.

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