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Abstract #3091

Ultrafast 3D Steady-State Chemical Exchange Saturation Transfer (CEST) MRI with Incoherent Sampling at 7T

Sugil Kim1, HoonJae Lee2, and Seong-Gi Kim2,3
1Siemens healthineers Ltd, Seoul, Republic of Korea, 2Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea, 3. Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea

CEST MRI exploits saturation transfer-induced proton exchange and its corresponding, indirect loss of water signal, has been shown to provide a novel contrast mechanism in MRI. However, CEST MRI is prone to B0 inhomogeneities. To resolve this problem, CEST MRI requires multiple-acquisition. To acquire z-spectrum of whole brain at ultrahigh field of 7T, there are multiple issues to be tackled; a prohibitively long acquisition time, potential high power deposition, and B0 drift during a long scanning time. In this work, we proposed the rapid steady-state CEST MRI pulse sequence incorporating with incoherent sampling in 3D segmented EPI at 7T

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