Abstract #3090

On the feasibility of a single scan B1+ correction scheme in combination with Multiple Interleaved Mode Saturation for quantitative CEST at 7 Tesla

Andrzej Liebert¹, Katharina Tkotz¹, Juergen Herrler², Patrick Liebig³, Rene Gumbrecht³, Arnd Doerfler², Frederik B. Laun¹, Michael Uder¹, Moritz Zaiss^2,4, and Armin M. Nagel^1,5

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ²Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁵Institute of Medical Physics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

In Chemical Exchange Saturation Transfer MR both B₁⁺-inhomogeneity correction and mitigation have their limitations, in particular if large field-of views shall be covered. To overcome these limitations a Multiple Interleaved Mode Saturation scheme was applied together with a linear B₁⁺ inhomogeneity correction method. Repeatability and reproducibility of the MTR_Rex metric for rNOE and APT were investigated. A combination of MIMOSA and a simple single point correction allows achieving repeatable and reproducible CEST contrast in whole brain with an acquisition time of 4min 54s.

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