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Abstract #3090

On the feasibility of a single scan B1+ correction scheme in combination with Multiple Interleaved Mode Saturation for quantitative CEST at 7 Tesla

Andrzej Liebert1, Katharina Tkotz1, Juergen Herrler2, Patrick Liebig3, Rene Gumbrecht3, Arnd Doerfler2, Frederik B. Laun1, Michael Uder1, Moritz Zaiss2,4, and Armin M. Nagel1,5
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 5Institute of Medical Physics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

In Chemical Exchange Saturation Transfer MR both B1+-inhomogeneity correction and mitigation have their limitations, in particular if large field-of views shall be covered. To overcome these limitations a Multiple Interleaved Mode Saturation scheme was applied together with a linear B1+ inhomogeneity correction method. Repeatability and reproducibility of the MTRRex metric for rNOE and APT were investigated. A combination of MIMOSA and a simple single point correction allows achieving repeatable and reproducible CEST contrast in whole brain with an acquisition time of 4min 54s.

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