Abstract #3095

Frequency-stabilized chemical exchange saturation transfer imaging with free induction decay readout

Ruibin Liu¹, Hongxi Zhang², Yi-Cheng Hsu³, Caixia Fu⁴, Yi Sun³, Dan Wu¹, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, ³MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁴Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

CEST imaging is highly sensitive to temporal B₀ drift, for which a frequency-stabilized CEST (FS-CEST) sequence was recently proposed by inserting a frequency stabilization module in front of the conventional non-frequency-stabilized CEST (NFS-CEST) sequence. Here, the frequency stabilization module in the FS-CEST sequence was further simplified by replacing the original gradient-echo readout with free induction decay (FID) readout. The proposed FS-CEST sequence with FID readout in the frequency stabilization module was validated in phantoms on a 3T Siemens Prisma scanner and in 15 volunteers on a 3T Philips Achieva scanner, both leading to improved CEST maps.

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