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Abstract #3096

Snapshot whole brain CEST MRI at 3T with 3D-EPI

Sebastian Mueller1, Rüdiger Stirnberg2, Suzan Akbey2, Philipp Ehses2, Klaus Scheffler1,3, Tony Stöcker2,4, and Moritz Zaiss1,5
1High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 3Department of Biomedical Magnetic Resonance, Eberhard Karls University Tuebingen, Tuebingen, Germany, 4Department of Physics and Astronomy, University of Bonn, Bonn, Germany, 5Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany

CEST MRI provides metabolite-based contrasts but often suffers from poor volume coverage or spatial resolution. We optimized and included a snapshot 3D-EPI readout and propose a suitable post-processing pipeline to generate CEST contrast in the whole brain at clinical B0=3T. It is shown that CEST MRI with 1.8mm isotropic nominal resolution at a field of view of 256x224x156mm³ is feasible within 4.3s per presaturation frequency offset. The approach is adaptable for any presaturation scheme. Exemplarily low power saturation was performed and fitted Lorentzian amplitudes gave a coefficient of variation <8.5% across three healthy subjects.

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