Gliomas are the most common primary brain tumour, whose staging depends on the IDH and 1p/19q status and is reflected in different prognoses and clincal management. CEST is a highly sensitive MRI technique detecting amide- and amine-containing mobile proteins. The CEST amides/amines ratio has been proposed as a measure of pH in stroke. We show that CEST amides/amines ratio is much more sensitive than separate amides and amines CEST in differentiating gliomas with the best prognosis (IDH-mutant_1p/19q-retained) from those with the worst prognosis (IDH-wildtype). The different shapes in CEST asymmetry spectra could also potentially help in glioma staging.