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Abstract #3107

Significant changes of APT signal in the Substantia Nigra and striatum of subacute PD mouse induced by MPTP

Quan Tao1, Peiwei Yi1, Zimeng Cai1, Yingjie Mei2, Zhifeng Chen1, Ruiyuan Liu1, Wufan Chen1, and Yanqiu Feng1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China

Chemical exchange saturation transfer (CEST) MRI has been widely investigated for the early diagnosis of neurological diseases, such as brain tumor and neurodegenerative disorders. The goal of this study was to develop an imaging biomarker for the future intervention and treatment of PD in clinic. For such purpose, a novel radial-sampling steady-state CEST sequence based ultrashort echo time (UTE) readout was used to acquire the Z-spectrum in the mouse brain of subacute PD model induced by MPTP.

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