Quan Tao1, Peiwei Yi1, Zimeng Cai1, Yingjie Mei2, Zhifeng Chen1, Ruiyuan Liu1, Wufan Chen1, and Yanqiu Feng1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China
Chemical exchange saturation transfer (CEST) MRI has been
widely investigated for the early diagnosis of neurological diseases, such as
brain tumor and neurodegenerative disorders. The goal of this study was to
develop an imaging biomarker for the future intervention and treatment of PD in
clinic. For such purpose, a novel radial-sampling steady-state CEST sequence
based ultrashort echo time (UTE) readout was used to acquire the Z-spectrum in
the mouse brain of subacute PD model induced by MPTP.
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