Abstract #3107

Significant changes of APT signal in the Substantia Nigra and striatum of subacute PD mouse induced by MPTP

Quan Tao¹, Peiwei Yi¹, Zimeng Cai¹, Yingjie Mei², Zhifeng Chen¹, Ruiyuan Liu¹, Wufan Chen¹, and Yanqiu Feng¹

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Philips healthcare, Guangzhou, China

Chemical exchange saturation transfer (CEST) MRI has been widely investigated for the early diagnosis of neurological diseases, such as brain tumor and neurodegenerative disorders. The goal of this study was to develop an imaging biomarker for the future intervention and treatment of PD in clinic. For such purpose, a novel radial-sampling steady-state CEST sequence based ultrashort echo time (UTE) readout was used to acquire the Z-spectrum in the mouse brain of subacute PD model induced by MPTP.

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