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Abstract #3108

Amide Proton Transfer imaging for differentiation of Tuberculomas from High-Grade Gliomas

Karthik Kulanthaivelu1, Sanita Raju2, Jitender Saini1, Atchayaram Nalini2, Nishanth Sadashiva3, Shashank Hegde4, Narayana Krishna Rolla5, and Indrajit Saha5
1Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India, 2Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India, 3Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India, 4Philips Healthcare, Bengaluru, India, 5Philips Health Systems, Philips India Ltd, Bengaluru, India

Amide proton transfer imaging was investigated for its potential to discriminate tuberculomas from high-grade gliomas. The diagnosis was confirmed by histopathology, CSF examination or response to anti-tubercular therapy. The MTRasym value of the Tuberculomas (mean 2.32± 0.50 s.d.) was significantly lower than high-grade gliomas (mean 4.32±0.84s.d.). Lower MTRasym values in tuberculomas are suggestive of relatively reduced mobile amide protons compared to the tumoral microenvironment. Perilesional elevated APT values in tuberculomas are a unique observation and may reflect a milieu of inflammation.

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