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Abstract #3109

Investigating the dependence of APT-CEST imaging in the human breast at 7 Tesla on the menstrual cycle

Lisa Loi1, Ferdinand Zimmermann2, Andreas Korzowski2, Jan-Eric Meissner2, Johannes Breitling2, Peter Bachert2, Mark Edward Ladd2, Heinz-Peter Schlemmer1, Sarah Schott3, Sebastian Bickelhaupt4, Steffen Goerke2, and Daniel Paech1
1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 3Gynecology, University Hospital Heidelberg, Heidelberg, Germany, 4German Cancer Research Center, Heidelberg, Germany

Compared to conventional dynamic contrast-enhanced MR-mammography, which is known to be significantly affected by the phase of the menstrual cycle, the menstrual cycle-related effect on APT CEST MRI in the human breast is still unknown. This is the first study investigating the influence of the menstrual cycle on APT CEST MRI in fibroglandular breast tissue of seven healthy premenopausal women. No significant signal intensity differences in fibroglandular breast tissue between the follicular and the luteal phase of the menstrual cycle were observed, which suggests that APT contrasts are comparable regardless of the phase of the menstrual cycle in premenopausal women.

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