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Abstract #3110

Relaxation-compensated APT CEST imaging in breast cancer diagnostics at 7T

Lisa Loi1, Ferdinand Zimmermann2, Andreas Korzowski2, Jan-Eric Meissner2, Peter Bachert2, Mark Edward Ladd2, Heinz-Peter Schlemmer1, Sebastian Bickelhaupt3, Steffen Goerke2, Sarah Schott4, and Daniel Paech1
1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 3German Cancer Research Center, Heidelberg, Germany, 4Gynecology, University Hospital Heidelberg, Heidelberg, Germany

Relaxation-compensated, fat-corrected and B1-corrected APT CEST MRI is a novel MR imaging technique that generates complementary information to conventional MR-mammography. In this study, the ability of this improved APT CEST metric was investigated in nine patients with newly diagnosed breast cancer. Compared to normal appearing fibroglandular breast tissue, significantly increased APT CEST signal intensities in breast cancer tissue were observed. Consequently, this MRI approach represents a contrast agent-free method that may enable a non-invasive differentiation of breast cancer and normal appearing breast tissue and, therefore, help to increase diagnostic accuracy in breast cancer imaging.

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