Relaxation-compensated, fat-corrected and B1-corrected APT CEST MRI is a novel MR imaging technique that generates complementary information to conventional MR-mammography. In this study, the ability of this improved APT CEST metric was investigated in nine patients with newly diagnosed breast cancer. Compared to normal appearing fibroglandular breast tissue, significantly increased APT CEST signal intensities in breast cancer tissue were observed. Consequently, this MRI approach represents a contrast agent-free method that may enable a non-invasive differentiation of breast cancer and normal appearing breast tissue and, therefore, help to increase diagnostic accuracy in breast cancer imaging.
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