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Abstract #3111

Induced Saturation Transfer Recovery Steady State (iSTRESS) for proton exchange rate imaging with MRI

Mehran Shaghaghi1 and Kejia Cai1,2,3
1Radiology, University of Illinois - Chicago, Chicago, IL, United States, 2Bioengineering, University of Illinois - Chicago, Chicago, IL, United States, 3Center for MR Research, University of Illinois - Chicago, Chicago, IL, United States

We present a novel method to induced saturation-transfer-recovery steady-states for determining proton exchange (kex) with low saturation power, short duration, and hence negligible SAR deposition. Our previous study has demonstrated that omega plotting with direct saturation (DS) signal removed can be used to map kex of healthy brains in vivo. However, omega plot, based on steady-state saturation assumption, requires long scanning time and potential high SAR deposition, which makes it non-applicable for clinical studies. Our suggested method, validated by simulations and phantom imaging, shows great promise for in vivo proton exchange rate imaging and clinical applications.

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