Abstract #3112

Layer-dependent Transient Saturation Transfer MRI at 7T

Catarina Rua¹, Sanne Kaalund², James B Rowe^2,3, Christopher T Rodgers¹, and Guy B Williams¹

¹Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ²Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ³Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom

The human cortical mantle has distinct non-uniform layers of gray matter. In this study we used ultra high-resolution MT-weighted imaging at 7T with varying mixing times to measure the transient effects of the magnetization suppression through the primary visual cortex (V1). The MT effect was monitored across different cortical depths to evaluate the effect of the macromolecular pool (MP) and myelination.

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