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Abstract #3113

Disparity between Glucose Exchange and Osmolality in Pathological Tissue using Dynamic Glucose Enhanced Magnetic Resonance Imaging (DGE-MRI)

Julius Juhyun Chung1, Geun Ho Im2, Jung Hee Lee2,3, Tao Jin1, and Seong-Gi Kim2
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Center for Neuroscience Imaging Research, Suwon, Republic of Korea, 3Radiology, Samsung Medical Center, Seoul, Republic of Korea

CEST has been used as a way to monitor glucose transport as a way of studying uptake as well as permeability. However, signal is not solely affected by exchange but also osmolality shifts with significant intravenous dosage. Using MCAO, we study disparity between these two effects and how they may lead to obfuscate signal sources. With the injection of glucose after the onset of ischemia, +1.2 ppm , -1.2 ppm, and MTR asymmetry curves behave quite differently. Both sides of the spectrum must be scrutinized to have a better picture of what is going on during glucose dosage.

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