CEST has been used as a way to monitor glucose transport as a way of studying uptake as well as permeability. However, signal is not solely affected by exchange but also osmolality shifts with significant intravenous dosage. Using MCAO, we study disparity between these two effects and how they may lead to obfuscate signal sources. With the injection of glucose after the onset of ischemia, +1.2 ppm , -1.2 ppm, and MTR asymmetry curves behave quite differently. Both sides of the spectrum must be scrutinized to have a better picture of what is going on during glucose dosage.