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Abstract #3114

Glucose Metabolism by Dynamical Glucose Enhanced imaging

Yu-Wen Chen1 and Dennis Wenhan Hwang2
1, IBMS N123, Academia Sinica, Taipei, Taiwan, 2IBMS, Academia Sinica, Taipei, Taiwan

Dynamic glucose-enhanced (DGE) images, detected by CEST, was used to provide direct information on glucose metabolism. It also provides the spatial distribution of the metabolic processes. The time-dependent glucose concentration variation in the striatum of HD shows that the glucose uptake in the HD mice striatum decreases with age. The groups of older than 9-11 weeks HD mice were easy to find the symptoms of HD, and their glucose uptaking also show a significant decrement. By contrast, WT mice show a mild decrease in the glucose uptake for the mice with similar age.

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