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Abstract #3115

Dynamic glucose-enhanced (DGE) MRI for brain tumors: a small-scale clinical observational study

Jianhua Mo1, Xiang Xu2,3, Xianglong Wang1, Linda Knutsson2,4, Akansha A Sehgal2,3, Peter C. M. van Zijl2,3, and Zhibo Wen1
1Zhujiang Hospital, Southern Medical University, Guangzhou, China, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden

Dynamic glucose-enhanced (DGE) MRI has shown potential for imaging glucose delivery and blood brain barrier permeability. Previous reports focused on the technical development of DGE and only a few clinical brain tumor cases have been reported. Here we incorporated the current DGE protocol into our routine MRI examination at 3T and performed a small-scale clinical observational study on patients with different types of brain tumors. Despite the technical challenges of DGE at clinical scanners, we observed different (non)-enhancement patterns with various brain tumor types.

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