MTR offers a measure of myelin content, but is also sensitive to non-physiological parameters. Quantitative MT methods remove these confounding effects; however, they require long scan times and complicated acquisition/analysis strategies. Selective inversion recovery is a simple method that may address many of these limitations, but requires long scan times and specialized inversion recovery sequences. The issue of long scan times was previously addressed through optimized sampling schemes. The need for specialized sequences is addressed herein by using a standard MP-RAGE sequence and modifying the SIR signal model. The resulting “turnkey” approach was tested numerically and applied in the brain.
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