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Abstract #3128

Concentration-independent absolute pH mapping using amide CEST-MRI at 9.4 T

Philip S. Boyd1, Johannes Breitling1, Mark E. Ladd1, Peter Bachert1, and Steffen Goerke1
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, we developed an absolute pH mapping method based on endogenous amide CEST-MRI which simultaneously compensates for concentration changes, the semi-solid magnetization transfer, and spillover dilution. This was realized by a ratiometric approach of two different B1 in combination with the inverse metric and polynomial Lorentzian-fitting of the amide signal. Compensation for concomitant effects was theoretically demonstrated in simulations and verified experimentally in protein model solutions and porcine brain lysates. Consequently, amide signal-based absolute pH mapping is now in principle also reliably applicable for tumor imaging which was previously prevented by the concomitant effects.

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