Abstract #3127

Investigation of the reliability in pH quantification with MR chemical exchange saturation transfer (CEST) power ratiometric imaging at 3 Tesla

Jie Liu¹, Zongwei Xu¹, Qi Liu², Hui Liu², Jian Xu², Xin Liu¹, Hairong Zheng¹, and Yin Wu¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²United Imaging Healthcare America, Houston, TX, United States

Chemical exchange saturation transfer (CEST) using iodinated agents has been tested for extracellular pH imaging on high-field animal scanners. However, the reliability in the pH quantification on low magnetic strengths remains elucidated. In this study, CEST imaging was performed on iobitridol phantom twice with a three-day interval at 3T. pH was quantified by ratioing iobitridol CEST effects at 5.6 ppm under B₁ of 1.0 and 2.0 μT. Results show accurate pH quantification in both scans. Good consistency of paired measures was observed between the two scans, suggesting the reliability of the method and its potential clinical applicability at 3T.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.