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Abstract #3127

Investigation of the reliability in pH quantification with MR chemical exchange saturation transfer (CEST) power ratiometric imaging at 3 Tesla

Jie Liu1, Zongwei Xu1, Qi Liu2, Hui Liu2, Jian Xu2, Xin Liu1, Hairong Zheng1, and Yin Wu1
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2United Imaging Healthcare America, Houston, TX, United States

Chemical exchange saturation transfer (CEST) using iodinated agents has been tested for extracellular pH imaging on high-field animal scanners. However, the reliability in the pH quantification on low magnetic strengths remains elucidated. In this study, CEST imaging was performed on iobitridol phantom twice with a three-day interval at 3T. pH was quantified by ratioing iobitridol CEST effects at 5.6 ppm under B1 of 1.0 and 2.0 μT. Results show accurate pH quantification in both scans. Good consistency of paired measures was observed between the two scans, suggesting the reliability of the method and its potential clinical applicability at 3T.

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