We present a fast 2D EPI multislice sequence that allows to acquire the APT-CEST contrast in 16 slices within 8 seconds. The fast CEST-EPI sequence was compared in vitro and in vivo with a steady-state CEST sequence, where the saturation is applied for 4 s for each frequency offset. The reduced acquisition time in the fast sequence can be used for measurement repetitions or additional MR examinations (e.g. MR spectroscopic imaging).