Abstract #3135

Quantitative magnetization transfer (MT) of tissue from subjects with multiple sclerosis using inhomogeneous MT (ihMT) data

Gopal Varma¹, Hemant Varma², Cody Callahan¹, Olivier M Girard³, Guillaume Duhamel³, Aaron K Grant¹, and David C Alsop¹

¹Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ³CNRS, CRMBM, Aix-Marseille Univ, Marseille, France

Quantitative magnetization transfer (MT) was carried out using inhomogeneous MT (ihMT) data, following optimization of an acquisition protocol. The optimized protocol was applied in ex-vivo brain tissue from a donor with multiple sclerosis (MS), as well as tissue containing an MS plaque. Parameter maps output from quantitative MT showed white and grey matter contrast, as well as a lower restricted or bound pool fraction in the area of the MS plaque from histology. Results from quantitative MT using ihMT were compared with those using selective inversion recovery, as well as quantitative outputs from diffusion tensor MRI.

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