Abstract #3136

Inhomogeneous magnetization transfer saturation (ihMTsat): efficient centric-encoded GRE implementation with B1 inhomogeneity correction

Christopher D Rowley^1,2, Zhe Wu^2,3, Ilana R. Leppert², Jennifer S.W. Campbell ², David A. Rudko^2,4,5, G. Bruce Pike⁶, and Christine L. Tardif^1,2,4

¹Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ²McConnell Brain Imaging Center, McGill Unversity, Montreal, QC, Canada, ³Techna Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Biomedical Engineering, McGill Unversity, Montreal, QC, Canada, ⁵Department of Neurology and Neurosurgery, McGill Unversity, Montreal, QC, Canada, ⁶Hotchkiss Brain Institute and Departments of Radiology and Clinical Neuroscience, University of Calgary, Calgary, AB, Canada

Inhomogeneous magnetization transfer (ihMT) contrast in the brain has been reported to be a myelin-specific biomarker, but can be impacted by B₁ inhomogeneities, reducing its accuracy. ihMT equations incorporating B₁correction assume a single excitation and readout, either a k-space line or plane, per saturation module. Here we use an arbitrary number of readout segments collected after an MT saturation preparation module. T₁ and B₁ variations are included in the signal equations to increase specificity of the contrast to the microstructure. The resulting implementation yields a balance between acquisition efficiency and contrast resolution for different brain imaging applications.

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