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Abstract #3136

Inhomogeneous magnetization transfer saturation (ihMTsat): efficient centric-encoded GRE implementation with B1 inhomogeneity correction

Christopher D Rowley1,2, Zhe Wu2,3, Ilana R. Leppert2, Jennifer S.W. Campbell 2, David A. Rudko2,4,5, G. Bruce Pike6, and Christine L. Tardif1,2,4
1Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 2McConnell Brain Imaging Center, McGill Unversity, Montreal, QC, Canada, 3Techna Institute, University Health Network, Toronto, ON, Canada, 4Department of Biomedical Engineering, McGill Unversity, Montreal, QC, Canada, 5Department of Neurology and Neurosurgery, McGill Unversity, Montreal, QC, Canada, 6Hotchkiss Brain Institute and Departments of Radiology and Clinical Neuroscience, University of Calgary, Calgary, AB, Canada

Inhomogeneous magnetization transfer (ihMT) contrast in the brain has been reported to be a myelin-specific biomarker, but can be impacted by B1 inhomogeneities, reducing its accuracy. ihMT equations incorporating B1 correction assume a single excitation and readout, either a k-space line or plane, per saturation module. Here we use an arbitrary number of readout segments collected after an MT saturation preparation module. T1 and B1 variations are included in the signal equations to increase specificity of the contrast to the microstructure. The resulting implementation yields a balance between acquisition efficiency and contrast resolution for different brain imaging applications.

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