Abstract #3138

High-resolution magnetization transfer ratio maps using spiral-phyllotaxis Cartesian FLASH and compressed sensing in under five minutes

Gabriele Bonanno^1,2,3, Tom Hilbert^4,5,6, Arun Joseph^1,2,3, Emilie Mussard^4,5,6, Christoph Forman⁷, Gian Franco Piredda^4,5,6, and Tobias Kober^4,5,6

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, ²Translational Imaging Center, sitem-insel AG, Bern, Switzerland, ³Departments of Radiology and Biomedical Research, University of Berne, Bern, Switzerland, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁶LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁷Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany

Magnetization Transfer Ratio (MTR) imaging may be a valuable tool for the diagnosis and follow-up of demyelinating diseases. However, MTR maps require long scan times for whole-brain coverage and high isotropic resolution. We present a novel MTR imaging method based on a spiral-phyllotaxis Cartesian FLASH sequence and compressed sensing, called MTRSparse, and compare it to fully sampled and parallel-imaging-accelerated acquisitions in healthy volunteers. MTRSparse showed good contrast and similar MTR values in comparison to the reference method with up to 87% reduction in acquisition time. This can help facilitate implementation of MTR imaging in the clinical practice.

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