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Abstract #3138

High-resolution magnetization transfer ratio maps using spiral-phyllotaxis Cartesian FLASH and compressed sensing in under five minutes

Gabriele Bonanno1,2,3, Tom Hilbert4,5,6, Arun Joseph1,2,3, Emilie Mussard4,5,6, Christoph Forman7, Gian Franco Piredda4,5,6, and Tobias Kober4,5,6
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, 2Translational Imaging Center, sitem-insel AG, Bern, Switzerland, 3Departments of Radiology and Biomedical Research, University of Berne, Bern, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 7Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany

Magnetization Transfer Ratio (MTR) imaging may be a valuable tool for the diagnosis and follow-up of demyelinating diseases. However, MTR maps require long scan times for whole-brain coverage and high isotropic resolution. We present a novel MTR imaging method based on a spiral-phyllotaxis Cartesian FLASH sequence and compressed sensing, called MTRSparse, and compare it to fully sampled and parallel-imaging-accelerated acquisitions in healthy volunteers. MTRSparse showed good contrast and similar MTR values in comparison to the reference method with up to 87% reduction in acquisition time. This can help facilitate implementation of MTR imaging in the clinical practice.

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