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Abstract #3139

Estimation of Glutamate-weighted CEST Contrast after Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor

Ayan Debnath1,2, Hari Hariharan2, Ravi Prakash Reddy Nanga2, Ravinder Reddy2, and Anup Singh1,3
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Center for Magnetic Resonance & Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Biomedical Engineering, All India Institute of Medical Science, New Delhi, India

Asymmetry in MT causes erroneous GluCEST computation. The study focuses on removal of MT effects from Z-spectra for better quantification of GluCEST contrast using in-vivo human volunteer at 7T and rat brain with tumor at 9.4T. Different lineshapes for modelling and fitting broad MT spectrum has been compared. Lorentzian lineshape provided significant difference between GluCEST contrast before and after MT removal and also preserves the gray-matter to white-matter glutamate concentration ratio validated with MR spectroscopic based estimation. After removal of MT effect using Lorentzian lineshape, the specificity of GluCEST to glutamate concentration increases which can helps better diagnosis of diseases.

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