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Abstract #3140

Variable-density Fast-Spin-Echo (FSE) for volumetric inhomogeneous Magnetization Transfer (ihMT) imaging

Manuel Taso1, Fanny Munsch1, Arnaud Guidon2, Olivier M. Girard3, Guillaume Duhamel3, David C. Alsop1, and Gopal Varma1
1Division of MRI research, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Global MR Applications and Workflow, GE Healthcare, Boston, MA, United States, 3CRMBM, Aix-Marseille Univ, CNRS, Marseille, France

While the original inhomogeneous magnetization transfer (ihMT) implementations for myelin imaging relied heavily on single-slice imaging, recent developments have enabled volumetric acquisitions using rapid gradient-echo sequences. But in vivo volumetric spin-echo acquisitions have been unexplored so far although they provide a theoretical advantage over GRE. We report here the implementation of a variable-density FSE with Compressed-Sensing for time-efficient volumetric ihMT imaging with high SNR. Provisional experiments show promising results even at high acceleration rates while also identifying areas for potential improvement, paving the way for future use of ihMT FSE for whole brain and potentially spinal cord imaging.

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