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Abstract #3141

Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T

Jianpan Huang1, Xiongqi Han1, Lin Chen2,3, Xiang Xu2,3, Peter C. M. van Zijl2,3, Jiadi Xu2,3, and Kannie W. Y. Chan1,2
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Relayed nuclear Overhauser enhancement (rNOE) imaging indirectly detects the aliphatic groups of biomolecules and can be used to diagnose protein or lipid signals and related pathology involving such signals. Current rNOE imaging has been studied mainly on high-field MRI scanners (≥7T). When implementing the technique on low clinical MRI fields (≤3T), rNOE contrast is more obscured by semisolid magnetization transfer contrast (MTC) and water direct saturation (DS). We developed a pulsed-CEST/MT method at 3T MRI that can suppress MTC and DS efficiently, not compromising rNOE contrast.

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