Abstract #3141

Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T

Jianpan Huang¹, Xiongqi Han¹, Lin Chen^2,3, Xiang Xu^2,3, Peter C. M. van Zijl^2,3, Jiadi Xu^2,3, and Kannie W. Y. Chan^1,2

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Relayed nuclear Overhauser enhancement (rNOE) imaging indirectly detects the aliphatic groups of biomolecules and can be used to diagnose protein or lipid signals and related pathology involving such signals. Current rNOE imaging has been studied mainly on high-field MRI scanners (≥7T). When implementing the technique on low clinical MRI fields (≤3T), rNOE contrast is more obscured by semisolid magnetization transfer contrast (MTC) and water direct saturation (DS). We developed a pulsed-CEST/MT method at 3T MRI that can suppress MTC and DS efficiently, not compromising rNOE contrast.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.